New York, 1980s
Alice Burns - a young book editor - is deep into a manuscript about the morass of family life. The observations within resonate, perhaps, because she has just watched her own family implode.
As she reads she wonders: When did the sadness start? And could it be that unhappiness is a choice?
Thus begins a great American epic which follows Alice as she navigates high school, first love and sexism at an elite college, a spell in 1970s Ireland, and a tragedy that sends her stateside as the US embraces a cowboy actor named Reagan.
But it is also the tale of her endlessly complex parents and brothers - how their destinies are written by the lies they tell themselves and others.
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