Florence, 1429. With shrewd investment, strategic alliance and sly manipulation, the Medici family have climbed to the top of Florentine society. But their success has left a slew of bitter enemies in their wake, enemies who will stop at nothing to usurp their power. When family patriarch Giovanni de Medici is struck down by a suspicious and fatal illness, he leaves the family's wealth and reputation in the hands of his sons, Cosimo and Lorenzo, to protect by any means necessary.